Alport syndrome

noun

Al·​port syndrome ˈal-ˌpȯrt- 

variants or Alport's syndrome

: a genetic disorder of the kidneys that is usually inherited as an X-linked trait, is typically more severe in males, and is characterized especially by blood in the urine, hearing loss, abnormalities of the eye, and progressive renal failure

Note: Alport syndrome is caused by mutations in genes encoding a type of collagen normally present in basement membranes.

Most victims of Alport syndrome experience progressive kidney failure, often requiring a kidney transplant or prolonged kidney dialysis.

—William Booth, The Washington Post